zylkene and zylkene plus product family shot
How It Works
Dosage Information

What is Zylkene?

Zylkene is formulated with alpha-casozepine, a natural ingredient derived from bovine hydrolyzed milk protein that has clinically proven calming properties.

Zylkene is a calming aid with an effect that’s ideal for short-term stressful events like fireworks or vet visits

What is Zylkene Plus?

Zylkene Plus includes alpha-casozepine + white fish muscle hydrolysate, which is naturally rich in bioactive marine peptides and supports adaptation, resilience, and cognitive function.

The combination promotes a sustained calming effect ideal for stressful periods of time or recurring situations like moving.

Key Benefits of Zylkene and Zylkene Plus:

  • Backed by real-world evidence1,2,3,4
  • Non-sedating and helps pets stay calm, without affecting personality
  • Zylkene is ideal for short-term use
  • Zylkene Plus is great for long-term use
  • Can be given with medications
  • Easy to give and highly palatable5

  • Uses high-quality ingredients

  • Lactose-free

zylkene and zylkene plus product image

Improve the quality of life for pets and their owners with Zylkene and Zylkene Plus:

  • Helps pets adapt to changes in their environment
  • Helps pets cope with unusual situations
  • Increases pets’ receptivity to behavior modification training
  • Use as the first line of defense against mild to moderate stressors
Zylkene 30ct bottles

Dosage Information

For short-term situations:

Begin administration of Zylkene classic 1-2 days before the anticipated event. Some animals may need earlier administration (5-7 days).

For long-term use:

Begin administration of Zylkene Plus 1-2 days before the anticipated period or change in routine. Some animals may need earlier administration (5-7 days). Use Zylkene Plus daily whenever the duration of use is expected to be at least one month. Using alongside a behavior modification program may help in these situations.

Palatable and
Easy to Use

Once daily administration supports compliance.
Capsules contain a palatable powder that appeals to both dogs and cats.

zylkene administration table

References:

1. Beata, C., Beaumont-Graff, E., Coll, V., Cordel, J., Marion, M., Massal, N., Marlois, N., & Tauzin, J. (2007). Effect of alpha-casozepine (Zylkene) in cats. Journal of Veterinary Behavior, 2(2), 40–46.
2. Beata, C., Beaumont-Graff, E., Diaz, C., Marion, M., Massal, N., Marlois, N., Muller, G., & Lefranc, C. (2007). Effects of alpha-casozepine (Zylkene) versus selegiline hydrochloride (Selgian, Anipryl) in dogs. Journal of Veterinary Behavior, 2(5), 175–183.

3. Porcheron G; Guénan C; Barichard A; Julié P, Brault J; Roy O; Fantini O; Garcia-Pedraza E. Study presented at International Society of Feline Medicine (ISFM) Congress 2024 CEBIPHAR – sent for publication.

4. Porcheron, G., Bodet, M., Poiron, K., Brault, J., Massal, N., Roy, O., & Fantini, O. (2023). Supplementation Effects of an Alpha-Casozepine and White Fish Muscle Hydrolyzed Complementary Feed on Canine Separation-Related Disorders and Quality of Life of Dogs and Their Pet Caregivers. Open Journal of Veterinary Medicine, 13(6), Article 6.
5. Data on File, Vetoquinol.